Article

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

2023-02-15

Abstract excerpt

<h4>Background</h4> Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5-year survival rates stands at only 9%. Triptolides have potent anti-tumor activity against different types of cancers, including pancreatic cancer, however poor solubility and toxicity limit their translation into clinical use. <h4>Methods</h4> We synthesized...

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Literature Corpus work: d4fbd70b-7aec-5f43-90be-2e055f4af0d6
DOI: 10.1101/2023.02.15.528599

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