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Article

Network pharmacology of triptolide in cancer cells: implications for transcription factor binding

2 Jul 2021

Abstract excerpt

Summary Background Triptolide is an active natural product, which inhibits cell proliferation, induces cell apoptosis, suppresses tumor metastasis and improves the effect of other therapeutic treatments in several cancer cell lines by affecting multiple molecules and signaling pathways, such as caspases, heat-shock proteins, DNA damage and NF-ĸB. Purpose We investigated the effect of triptolide towards NF-ĸB and...

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PMID: 34213719
DOI: 10.1007/s10637-021-01137-y

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