Article

Wnt activation-induced disturbance of cell competition causes diffuse invasion of transformed cells through upregulation of NF-κB-mediated MMP21

2022-12-15

Abstract excerpt

<title>Abstract</title> <p>Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into the apical lumen via cell competition. However, the internal or external factors that compromise cell competition and provoke carcinogenesis remains unknown. In this study, we examined the effect of sequential accumulation of gene mutations, mimicking multi-sequential carcinog...

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Literature Corpus work: d4ccb7f7-6777-5c9a-a80d-958c104f332a
DOI: 10.21203/rs.3.rs-2314559/v1

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