Article

Harnessing the Cooperative Function of Duplex From pre-miR-16 Hairpin to Simultaneously Inhibit VEGF and Hypoxia Pathways in Human Non-Small Cell Lung Cancer

2026-04-22

Abstract excerpt

<title>Abstract</title> <p>Resistance to anti-angiogenic therapy remains a major obstacle in non–small cell lung cancer (NSCLC). Although bevacizumab effectively neutralizes VEGFA and suppresses neovascularization, its clinical benefit is often transient. Here, we demonstrate that VEGFA inhibition paradoxically intensifies intratumoral hypoxia, leading to stabilization of HIF1A and activation of a compensatory pr...

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Literature Corpus work: d4c8ea8c-b388-5296-b477-f1baf7531521
DOI: 10.21203/rs.3.rs-8912330/v1

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