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Article

NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment.

Cancer letters - 1 Oct 2016

Broggini Thomas, Wüstner Marie, Harms Christoph, Stange Lena, Blaes Jonas, Thomé Carina, Harms Ulrike, Mueller Susanne, Weiler Markus, Wick Wolfgang, Vajkoczy Peter, Czabanka Marcus

Abstract excerpt

Hypoxia-regulated molecules play an important role in vascular resistance to antiangiogenic treatment. N-myc downstream-regulated-gene 1 (NDRG1) is significantly upregulated during hypoxia in glioma. It was the aim of the present study to analyze the role of NDRG1 on glioma angiogenesis and on antiangiogenic treatment. Orthotopically implanted NDRG1 glioma showed reduced tumor growth and vessel density compared...

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Source

Identifiers

PMID: 26297987
DOI: 10.1016/j.canlet.2015.06.026

Genes

TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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