Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.

Molecular biology of the cell - 15 Jan 2015

Jain Shweta, Farías Ginny G, Bonifacino Juan S

Abstract excerpt

Neurons are highly polarized cells having distinct somatodendritic and axonal domains. Here we report that polarized sorting of the Cu(2+) transporter ATP7B and the vesicle-SNARE VAMP4 to the somatodendritic domain of rat hippocampal neurons is mediated by recognition of dileucine-based signals in the cytosolic domains of the proteins by the σ1 subunit of the clathrin adaptor AP-1. Under basal Cu(2+) conditions,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cation Transport Proteins
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Copper

Share to Copper-Transporting ATPases

Share to Leucine

Share to Microscopy, Confocal

Share to R-SNARE Proteins

Share to trans-Golgi Network

Source

Open in PubMed Open full text

Identifiers

PMID: 25378584
DOI: 10.1091/mbc.E14-07-1177
PMCID: PMC4294670

Genes

VAMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.PMID 25378584Read ↗

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7BSemantic proximity Read ↗

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.Semantic proximity Read ↗

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial ContentSemantic proximity Read ↗

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factorsSemantic proximity Read ↗

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.Semantic proximity Read ↗

Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde trafficking.Semantic proximity Read ↗

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.Semantic proximity Read ↗

Wilson disease-causing mutations in the carboxyl terminus of ATP7B regulates its localization and Golgi exit selectively in the unpolarized cells.Semantic proximity Read ↗

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Semantic proximity Read ↗

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.Semantic proximity Read ↗

Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.Semantic proximity Read ↗

NON-REDUNDANT ROLES OF COPPER TRANSPORTERS ATP7A AND ATP7B IN NORADRENERGIC SIGNALINGSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.