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Article

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

2020-07-14

Abstract excerpt

Missense mutations that give rise to protein misfolding are rare, but collectively, defective protein folding diseases are consequential. Folding deficiencies are amenable to pharmacological correction (pharmacochaperoning), but the underlying mechanisms remain enigmatic. Ibogaine and its active metabolite noribogaine correct folding defects in the dopamine transporter (DAT), but they rescue only a very limited nu...

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Literature Corpus work
d4af2a0e-7512-5947-9f31-ee17a22b31d7
DOI
10.1101/2020.07.14.202325
Open publication

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A tropane-based ibogaine analog rescues folding-deficient SERT and DATDOI 10.1101/2020.07.14.202325
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