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Article

Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

11 Mar 2010

Abstract excerpt

Movement disorders represent a significant societal burden for which therapeutic options are limited and focused on treating disease symptomality. Early-onset torsion dystonia (EOTD) is one such disorder characterized by sustained and involuntary muscle contractions that frequently cause repetitive movements or abnormal postures. Transmitted in an autosomal dominant manner with reduced penetrance, EOTD is caused...

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PMID: 20223934
DOI: 10.1242/dmm.003715

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