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Article

Comprehensive bioinformatic analysis identifies potential therapeutic drugs for CryAB (R120G)-related cardiomyopathy.

BMC cardiovascular disorders - 30 Aug 2025

Zheng Jiaqi, Liu Yuyang, Wang Jie, Hu Jiajia, Qiu Wei, Su Ming

Abstract excerpt

CryAB, known as Alpha-B Crystallin, has also been shown to bind and increase the unfolding force of the filamentous protein. Mutation of CryAB at R120G causes serious cardiomyopathy but lacks ideal therapeutic drugs. In the present study, we constructed CryAB (R120G)-transgenic (TG) mice. One hundred and four differentially expressed genes (DEGs) in heart tissues of TG mice were screened through RNA sequencing....

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Source

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Identifiers

PMID: 40885924
DOI: 10.1186/s12872-025-04897-0
PMCID: PMC12398125

Genes

SCN5A
TG
ACACB
ACSF2
CLCN1
DHTKD1
HSPA1B
NKTR
RPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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