Article

Gut colonization by <i>Bacteroides fragilis</i> at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic mice

2025-06-05

Abstract excerpt

Type 1 diabetes (T1D) in humans is associated with higher Bacteroidetes : Firmicutes ratio and higher abundance of Bacteroides genus members. Bacteroides fragilis (BF) is an integral component of the human colonic commensal microbiota. Here, we show that gut colonization of specific pathogen-free (SPF) non-obese diabetic (NOD) mice by BF at a juvenile age induces a pro-inflammatory immune response and accelerated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a229d074-c4bd-5f22-8ac1-12c6d969a383
DOI: 10.1101/2025.06.02.657398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gut colonization by <i>Bacteroides fragilis</i> at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic miceDOI 10.1101/2025.06.02.657398Read

Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in MiceSemantic proximity Read

The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes OnsetSemantic proximity Read

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel DiseasesSemantic proximity Read

A Maternal Gluten-Free Diet Reduces Inflammation and Diabetes Incidence in the Offspring of NOD MiceSemantic proximity Read

A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetesSemantic proximity Read

Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onsetSemantic proximity Read

Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?Semantic proximity Read

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic miceSemantic proximity Read

Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in miceSemantic proximity Read

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient miceSemantic proximity Read

Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD miceSemantic proximity Read

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.Semantic proximity Read