Article

In vivo screen identifies LXR agonism potentiates sorafenib killing of hepatocellular carcinoma

2019-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Existing drug therapies for hepatocellular carcinoma (HCC), including sorafenib, extend patient survival by only three months. We sought to identify novel druggable targets for use in combination with sorafenib to increase its efficacy. We implemented an in vivo genetic screening paradigm utilizing a library of 43 genes-of-interest expressed in the context of repopulation of the injured livers...

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Literature Corpus work: d47ae784-54b1-594b-bdc9-2c35fd5b1d61
DOI: 10.1101/668350

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