Article

Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation

2023-09-22

Abstract excerpt

Desmosomes are transmembrane protein complexes that contribute to cell-cell adhesion in epithelia and other tissues. Here, we report the discovery of frequent genetic alterations in the desmosome in human cancers, with the strongest signal seen in cutaneous melanoma where desmosomes are mutated in >70% of cases. In primary but not metastatic melanoma biopsies, the burden of coding mutations in desmosome genes asso...

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Literature Corpus work: d450b895-c32f-5a86-b489-a04eb953f8aa
DOI: 10.1101/2023.09.19.558457

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