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Article

Advanced organoid models for targeting Kras-driven lung adenocarcinoma in drug discovery and combination therapy

24 Apr 2025

Abstract excerpt

BACKGROUND: Lung cancer remains one of the most challenging diseases to treat due to its heterogeneity. Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutations are genetic drivers in numerous cancer types including lung adenocarcinoma (LUAD). Despite recent advances in KRAS-targeted therapies, treatment resistance and limited therapeutic options necessitate advanced preclinical models, such as organoids, to...

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PMID: 40275403
DOI: 10.1186/s13046-025-03385-9

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