Article

Primate-specific SSX1 is required for CPSF6-dependent spermatocyte transcription and human fertility

2026-02-16

Abstract excerpt

<title>Abstract</title> <p> Genetic variation is a major cause of male infertility, and defining the underlying mechanisms is essential for developing effective interventions. <italic>SSX1</italic> is a primate specific gene whose deficiency has been linked to sperm malformations in humans and cynomolgus monkeys, yet its pathogenic mechanism remains unclear. Here, by whole exome sequencing of a cohort of 536 m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3e63ad0-0faf-59c4-8ae4-d08a38d28e27
DOI: 10.21203/rs.3.rs-8516172/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Primate-specific SSX1 is required for CPSF6-dependent spermatocyte transcription and human fertilityDOI 10.21203/rs.3.rs-8516172/v1Read

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.Semantic proximity Read

Progress in the genetic studies of spermatogenesis abnormalities.Semantic proximity Read

Loss-of-function variant in TEX44 cause male infertility with asthenoteratozoospermia in humans and miceSemantic proximity Read

Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencingSemantic proximity Read

Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.Semantic proximity Read

Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failureSemantic proximity Read

Single-cell sequencing in non-obstructive azoospermia: insights from primary and re-analysis studiesSemantic proximity Read

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertilitySemantic proximity Read

Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility.Semantic proximity Read

Genes Regulating Spermatogenesis and Sperm Function Associated With Rare DisordersSemantic proximity Read

Exome sequencing and functional analyses revealedCETN1variants leads to impaired cell division and male fertilitySemantic proximity Read

scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermiaSemantic proximity Read