Article
Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.
Asian journal of andrology - 1 Jan 2000
Cannarella Rossella, Condorelli Rosita A, Paolacci Stefano, Barbagallo Federica, Guerri Giulia, Bertelli Matteo, La Vignera Sandro, Calogero Aldo E
Abstract excerpt
A large proportion of patients with idiopathic spermatogenic failure (SPGF; oligozoospermia or nonobstructive azoospermia [NOA]) do not receive a diagnosis despite an extensive diagnostic workup. Recent evidence has shown that the etiology remains undefined in up to 75% of these patients. A number of genes involved in germ-cell proliferation, spermatocyte meiotic divisions, and spermatid development have been...
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