Article

Linking Unfolded Protein Response to Ovarian Cancer Cell Fusion

2021-09-27

Abstract excerpt

<h4>Background: </h4> Polyploid giant cancer cells (PGCCs) have been observed in epithelial ovarian tumors. They can resist antimitotic drugs, thus participating in tumor maintenance and recurrence. Despite their origin remains unclear, PGCC formation seems to be enhanced by conditions that trigger the unfolded protein response (UPR) such as hypoxia or chemotherapeutic treatments. Hypoxia has been shown to promote...

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Literature Corpus work: d3d7326b-94fd-5242-9cbf-7161e146e8fc
DOI: 10.21203/rs.3.rs-757674/v1

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