Article

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradation

2022-11-09

Abstract excerpt

<title>Abstract</title> <p>The interplay between NF-κB signaling and autophagy regulates inflammatory signaling in different cellular contexts and in response to different stimuli. The impairment of this crosstalk may play a role in chronic inflammation and in tumorigenesis. However, the molecular mechanism by which these two pathways interact to regulate the inflammatory response remains elusive. By using bioche...

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Literature Corpus work: d3b2cc08-8763-52e3-91f0-24ca6282e995
DOI: 10.21203/rs.3.rs-2222474/v1

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