Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

1 Jan 2012

Abstract excerpt

The NF-κB signaling system and the autophagic degradation pathway are crucial cellular survival mechanisms, both being well conserved during evolution. Emerging studies have indicated that the IKK/NF-κB signaling axis regulates autophagy in a context-dependent manner. IKK complex and NF-κB can enhance the expression of Beclin 1 and other autophagy-related proteins and stimulate autophagy whereas as a feedback...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Glycation End Products research
Share to Autophagy in Disease and Therapy
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22899934
DOI: 10.1155/2012/849541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging ProcessPMID 22899934Read ↗

IKK connects autophagy to major stress pathwaysSemantic proximity Read ↗

Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancerSemantic proximity Read ↗

IKK-dependent, NF-κB-independent control of autophagic gene expressionSemantic proximity Read ↗

Life, death, and autophagy in cancer: NF-κB turns up everywhereSemantic proximity Read ↗

Fibroblast orchestration of inflammaging via NF-kB activationSemantic proximity Read ↗

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB)- a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's DiseaseSemantic proximity Read ↗

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγSemantic proximity Read ↗

NF-κB: a key role in inflammatory diseasesSemantic proximity Read ↗

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradationSemantic proximity Read ↗

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradationSemantic proximity Read ↗

p65/RelA Modulates <i>BECN1</i> Transcription and AutophagySemantic proximity Read ↗

IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.