Article

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradation

2022-11-02

Abstract excerpt

The interplay between NF-κB signaling and autophagy regulates inflammatory signaling in different cellular contexts and in response to different stimuli. The impairment of this crosstalk may play a role in chronic inflammation and in tumorigenesis. However, the molecular mechanism by which these two pathways interact to regulate the inflammatory response remains elusive. By using biochemical analysis and imaging t...

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Literature Corpus work: fbc6bc02-65af-506e-a2d4-0ff31156757b
DOI: 10.1101/2022.11.02.514846

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