Article

Role of CYP3A5 in modulating androgen receptor signaling and its relevance to African American men with prostate cancer

2020-01-25

Abstract excerpt

<h4>Background</h4> Androgen receptor signaling is crucial for prostate cancer growth and is regulated by intratumoral CYP3A5. As African American (AA) men often carry the wild type CYP3A5 and express high level of CYP3A5 protein, we tested the effect of blocking the wild type CYP3A5 in prostate cancer cells from AA men on androgen receptor signaling. CYP3A5 processes several commonly prescribed drugs and many of...

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Literature Corpus work: d38a6c43-ddc2-53de-afdf-ab930ff534a2
DOI: 10.1101/2020.01.24.918920

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