Article

Racial differences in androgen metabolism and receptor signaling in prostate cancer

2021-04-01

Abstract excerpt

Dihydrotestosterone (DHT) and testosterone (T) mediated androgen receptor (AR) nuclear translocation initiates transcription of AR target genes that are pivotal for prostate cancer (PrCa) development and progression. Here we provide data indicating that in contrast to European American (EA) men, African American (AA) men with localized PrCa can exploit an alternative progesterone-androsterone-5α-androstanedione pa...

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Literature Corpus work: 75d2275a-7591-5102-a3d7-70b4b1fc3fda
DOI: 10.1101/2021.03.31.437727

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