Article
GLMEEMSAL epitope common in different isoforms of hMena elicits in vitro activation of cytotoxic T cells and stimulates specific antitumor immunity in BALB/c mice.
International immunopharmacology - 1 Mar 2018
Don-López Christian Azucena, Monroy-García Alberto, Weiss-Steider Benny, Rocha-Zavaleta Leticia, Hernández-Montes Jorge, García-Rocha Rosario, Mora-García María de Lourdes
Abstract excerpt
BACKGROUND: Alternative expression of human ortholog of murine Mena (hMena) hMena/hMena11a and hMena/hMenaΔv6 isoforms regulate the invasiveness and metastatic potential of tumor cells. It is then important to identify epitopes of these proteins that can elicit antitumor immune response to contribute to the elimination of cells with metastatic potential. METHODS: We assayed the capacity of the peptide GLMEEMSAL,...
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