Article

Novel In Vitro Models for Cell Differentiation and Drug Transport Studies of the Human Intestine

2023-08-30

Abstract excerpt

Still, the most common in vitro model for absorption, distribution, metabolism and excretion (ADME) purposes is the Caco-2 cell line. However, clear differences in gene- and protein expression towards the small intestine and an at best fair prediction accuracy of intestinal drug absorption restrict the usefulness as model for intestinal epithelial cells. To overcome these limitations, we evaluated a panel of low-p...

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Literature Corpus work: d32a82d4-32ab-5ff3-a717-86a0747e14fb
DOI: 10.20944/preprints202308.1998.v1

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