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Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNF-α antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure

2021-06-02

Abstract excerpt

<h4>Background</h4> A feed-forward pathological signaling loop generated by TNFα and IFN-γ in inflamed lung tissue, driving CXCL-10 (IP-10) and CXCL-9 chemokine-mediated activated T-cell and monocyte/macrophage tissue recruitment, may define, sustain and amplify the inflammatory biology of lethal COVID-19 respiratory failure. <h4>Methods</h4> To assess TNFα-antagonist therapy, 18 hospitalized adults with hypoxic r...

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Literature Corpus work
d3270574-044c-56be-ae9d-8914d8cc0c7d
DOI
10.1101/2021.05.29.21258010
Open publication

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Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNF-α antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failureDOI 10.1101/2021.05.29.21258010
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