Article
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Epilepsia - 1 Jun 2018
Baker Erin M, Thompson Christopher H, Hawkins Nicole A, Wagnon Jacy L, Wengert Eric R, Patel Manoj K, George Alfred L, Meisler Miriam H, Kearney Jennifer A
Abstract excerpt
OBJECTIVE: De novo mutations of SCN8A, encoding the voltage-gated sodium channel NaV 1.6, have been associated with a severe infant onset epileptic encephalopathy. Individuals with SCN8A encephalopathy have a mean age of seizure onset of 4-5 months, with multiple seizure types that are often refractory to treatment with available drugs. Anecdotal reports suggest that high-dose phenytoin is effective for some...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.