Article

Elexacaftor/Tezacaftor/Ivacaftor alters branching morphogenesis of the mouse embryonic lung

2021-11-04

Abstract excerpt

<h4>Introduction</h4> CFTR modulators triple combo-therapy Elexacaftor/Tezacaftor/Ivacaftor (ETI) has proven to clinically benefit homozygous and heterozygous F508del patients. As a result, an increasing number of pregnancies is expected. Studies of the potential impact of these modulators on the development of the foetus are mandatory. <h4>Materials</h4> We used the early mouse embryonic lung organ culture mode...

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Literature Corpus work: d283c23f-0181-5998-be67-5257eb611486
DOI: 10.1101/2021.11.01.466814

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