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FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells

15 Feb 2023

Abstract excerpt

Fibroblast growth factor (FGF) signaling is known to play an important role in lung organogenesis. However, we recently demonstrated that FGF10 fails to induce branching in human fetal lungs as is observed in mouse. Our previous human fetal lung RNA sequencing data exhibited increased FGF18 during the pseudoglandular stage of development, suggestive of its importance in human lung branching morphogenesis. Whereas...

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PMID: 36791060
DOI: 10.1152/ajplung.00316.2022

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