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Autophagy Is Impaired in Fetal Hypoplastic Lungs and Rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles

7 Jun 2022

Abstract excerpt

Abstract Rationale Pulmonary hypoplasia secondary to congenital diaphragmatic hernia is characterized by reduced branching morphogenesis, which is responsible for poor clinical outcomes. Administration of amniotic fluid stem cell extracellular vesicles (AFSC-EVs) rescues branching morphogenesis in rodent fetal models of pulmonary hypoplasia. Herein, we hypothesized that AFSC-EVs exert their regenerative potential...

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Share to Congenital Anomalies and Fetal Surgery
Share to Congenital Diaphragmatic Hernia Studies
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PMID: 35671495
DOI: 10.1164/rccm.202109-2168oc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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