Article

Sensitive cluster-free differential expression testing.

2023-03-10

Abstract excerpt

Comparing molecular features, including the identification of genes with differential expression (DE) between conditions, is a powerful approach for characterising disease-specific phenotypes. When testing for DE in single-cell RNA sequencing data, current pipelines first assign cells into discrete clusters (or cell types), followed by testing for differences within each cluster. Consequently, the sensitivity and...

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Literature Corpus work: d2669207-f52a-5669-b286-372125b32572
DOI: 10.1101/2023.03.08.531744

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