Article

HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics

2023-01-07

Abstract excerpt

In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, but only a small fraction of them may actually be perturbed. Here, using simulations, we demonstrate that the standard approach to single cell analysis fails to isolate the subset of affected case cells and their markers when either the affected subset is small, or when the s...

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Literature Corpus work: 3fd2e562-e1b6-5e77-8cab-07c719d08516
DOI: 10.1101/2023.01.06.523013

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