Article

Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer

2023-09-27

Abstract excerpt

<title>Abstract</title> <p><italic>ARID1A</italic>, an epigenetic tumor suppressor, is the most common gene mutation in clear-cell ovarian cancers (CCOCs). CCOCs are often resistant to standard chemotherapy and lack effective therapies. We hypothesized that <italic>ARID1A </italic>loss would increase CCOC cell dependency on chromatin remodeling and DNA repair pathways for survival. We demonstrate that combining B...

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Literature Corpus work: d262611d-4cc4-5e62-9238-d7329e4f6b5e
DOI: 10.21203/rs.3.rs-3314138/v1

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