Article

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

2021-02-17

Abstract excerpt

<h4>Summary</h4> Ovarian clear cell carcinoma (OCCC) is a rare but chemorefractory tumor. About 50% of all OCCC patients have inactivating mutations of ARID1A a member of the SWI/SNF chromatin remodeling complex. Members of the SWI/SNF remodeling have emerged as regulators of the energetic metabolism of mammalian cells, however the role of ARID1A as a modulator of the mitochondrial metabolism in OCCCs is yet to b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dd1ce67-df07-5c4c-af16-8524c3d185ff
DOI: 10.1101/2021.02.17.431266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the OvariesDOI 10.1101/2021.02.17.431266Read

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the OvariesSemantic proximity Read

Treatment Strategies for ARID1A-Deficient Ovarian Clear Cell CarcinomaSemantic proximity Read

Functional characterisation of driver events in ovarian clear cell carcinomaSemantic proximity Read

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategiesSemantic proximity Read

Potential therapeutic targets in ARID1A-mutated cancers.Semantic proximity Read

Acquired Evolution of Mitochondrial Metabolism Regulated by HNF1B in Ovarian Clear Cell CarcinomaSemantic proximity Read

The target therapy of ovarian clear cell carcinomaSemantic proximity Read

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP productionSemantic proximity Read

The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis.Semantic proximity Read

Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancerSemantic proximity Read

Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.Semantic proximity Read

Aberrant SWI/SNF Complex Members Are Predominant in Rare Ovarian Malignancies—Therapeutic Vulnerabilities in Treatment-Resistant SubtypesSemantic proximity Read