Article

Work horse strain <i>Clostridioides difficile</i> 630Δ <i>erm</i> is oblivious to its anaerobic lifestyle

2020-01-08

Abstract excerpt

The laboratory reference strain 630Δ erm of the anaerobic human pathogen Clostridioides difficile is characterized by a remarkable high oxygen tolerance. We show that an amino acid exchange in the DNA binding domain of the hydrogen peroxide sensor PerR results in a constitutive derepression of PerR-controlled genes and thus in an oxidative stress response even under anaerobic conditions. This questions the model...

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Literature Corpus work: d20077f6-35a0-54b7-af40-0ab5f7a49204
DOI: 10.1101/2020.01.07.897181

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