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Trisomy 21 and the Brain

1 Jul 2004

Abstract excerpt

In fetuses with Down syndrome, neurons fail to show normal dendritic development, yielding a "tree in winter" appearance. This developmental failure is thought to result in mental retardation. In adults with Down syndrome, neuronal loss is dramatic and neurofibrillary and neuritic Abeta plaque pathologies are consistent with Alzheimer disease. These pathological changes are thought to underlie the...

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PMID: 15290893
DOI: 10.1093/jnen/63.7.679

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