Article

Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions

2026-03-17

Abstract excerpt

Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer’s disease (AD). Beyond gene-dosage imbalance, trisomy 21 induces widespread transcriptional, metabolic, and proteomic remodeling that establishes a chronic state of proteotoxic and oxidative stress from early development. Increasing evidence ide...

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Literature Corpus work: 19facb2b-a4f0-5e1a-ba6d-34a050286605
DOI: 10.20944/preprints202603.1305.v1

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