Article

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

2020-05-29

Abstract excerpt

COVID-19 is an infectious disease caused by SARS-CoV-2, which enters host cells via the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal and malignant models and tissues from the aerodigestive and respiratory tracts, we investigated the expression and regulation of ACE2 and TMPRSS2 . We find that ACE2 expression is restricted to a select population of highly epithelial cells. Notably, infection...

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Literature Corpus work: f52f4eca-dae8-51ce-82eb-35917b002e51
DOI: 10.1101/2020.05.28.122291

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