Amyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination

Abstract excerpt

Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer’s disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes to subtle memory deficits observed during the preclinical stage. The heterogenous emergence of Aβ deposition may selectively impact certain memory domains, which rely on distinct underlying neural circuits. In this context, we...

Topics

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• Arousal
• Attention
• Executive Function
• Frontotemporal Dementia
• Memory, Short-Term
• Neuropsychological Tests
• Psychomotor Performance
• Visual Perception

Identifiers and source

Literature Corpus work

d199da22-5c32-5449-9408-b0230b185bd6

DOI

10.1101/2024.08.23.609449