Article
Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis.
PloS one - 1 Jan 2011
Zuber Peter, Chauhan Shefali, Pilaka Praseeda, Nakano Michiko M, Gurumoorthy Sairam, Lin Ann A, Barendt Skye M, Chi Bui Khanh, Antelmann Haike, Mäder Ulrike
Abstract excerpt
Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. The regulon that it governs is comprised of over 120 genes based on microarray analysis, although it is not known how many of these are under direct Spx control. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products that are conserved in low %GC Gram-positive bacteria. Using a...
Topics
- Bacillus subtilis
- Base Sequence
- Biomarkers
- Disulfides
- Gene Expression Profiling
- Genes, Regulator
- Genetic Complementation Test
- Homeostasis
- Iron
- Molecular Sequence Data