Article
On the limits of active module identification.
Briefings in bioinformatics - 2 Sept 2021
Lazareva Olga, Baumbach Jan, List Markus, Blumenthal David B
Abstract excerpt
In network and systems medicine, active module identification methods (AMIMs) are widely used for discovering candidate molecular disease mechanisms. To this end, AMIMs combine network analysis algorithms with molecular profiling data, most commonly, by projecting gene expression data onto generic protein-protein interaction (PPI) networks. Although active module identification has led to various novel insights...
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