Article

Mutafy: A webserver to identify high quality mutant protein structures in the Protein Data Bank

2023-03-24

Abstract excerpt

Changes in the amino acid sequence of proteins resulting from nonsynonymous variants in the genome, can have significant effects on protein folding, stability, dynamics, and function, which may ultimately lead to diseases. The analysis of large sets of disease associated variants is a common approach for the study of pathogenic mechanisms. In-silico mutagenesis experiments based on wildtype structures of target p...

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Literature Corpus work: d14a1184-1bc4-5041-9d07-74b53c707107
DOI: 10.1101/2023.03.22.533870

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