Article
Mechanistic approaches to Parkinson's disease pathogenesis.
Brain pathology (Zurich, Switzerland) - 1 Oct 2002
Betarbet Ranjita, Sherer Todd B, Di Monte Donato A, Greenamyre J Timothy
Abstract excerpt
Parkinson's disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration and development of cytoplasmic proteinaceous aggregates known as Lewy bodies. Although the pathogenic mechanisms responsible for PD are not completely understood, many clues have come from biochemical, epidemiological, and genetic studies. Mutations in certain genes found in rare, familial cases of...
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