Article

Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells

2021-12-30

Abstract excerpt

Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects to cell function and cell viability, often contributing to disease pathogenesis. Many proteins prone to exodosis reside in the ER/SR via an ER retention/retrieval sequence (ERS) and are i...

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Literature Corpus work: d112e2dc-587a-5019-b7e0-9ec8063e320e
DOI: 10.1101/2021.12.29.474463

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