Article

Whole-Genome and Transcriptome Sequencing Identified NOTCH2 and HES1 As Potential Markers of Response to Imatinib in Desmoid Tumor (Aggressive Fibromatosis): A Phase II Trial Study

2021-10-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Desmoid tumor, also known as aggressive fibromatosis, is well-characterized by abnormal Wnt/β-catenin signaling. Various therapeutic options, including imatinib, are available to efficiently treat desmoid tumor. However, molecular mechanism of why imatinib works remains poorly understood. Here, we describe the potential roles of <italic>NOTCH2</italic> and <ital...

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Literature Corpus work: d1025855-aba4-5860-9055-3ec323a75538
DOI: 10.21203/rs.3.rs-993539/v1

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