Article
Novel intra-genic large deletions of CTNNB1 gene identified in WT desmoid-type fibromatosis.
Genes, chromosomes & cancer - 1 Oct 2018
Colombo Chiara, Urbini Milena, Astolfi Annalisa, Collini Paola, Indio Valentina, Belfiore Antonino, Paielli Nicholas, Perrone Federica, Tarantino Giuseppe, Palassini Elena, Fiore Marco, Pession Andrea, Stacchiotti Silvia, Pantaleo Maria Abbondanza, Gronchi Alessandro
Abstract excerpt
A wait and see approach for desmoid tumors (DT) has become part of the routine treatment strategy. However, predictive factors to select the risk of progressive disease are still lacking. A translational project was run in order to identify genomic signatures in patients enrolled within an Italian prospective observational study. Among 12 DT patients (10 CTNNB1-mutated and 2 wild type) enrolled from our...
Topics
- Abdominal Neoplasms
- Adaptor Proteins, Signal Transducing
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Adult
- Female
- Desmoid Tumors
- Gene Deletion
- Genomics