Article

Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

2018-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis (fALS) induce the protein to misfold and aggregate. To date, missense mutations at more than 80 different amino acid positions have been associated with disease. How these mutations perturb native structure to heighten the propensity to misfold and aggregate is unclear. One potential mechanism that...

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Literature Corpus work: d0df446b-9322-5b82-9a51-2897b082a601
DOI: 10.1101/301309

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