Article
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment cell & melanoma research - 1 May 2015
Vogel Celia J, Smit Marjon A, Maddalo Gianluca, Possik Patricia A, Sparidans Rolf W, van der Burg Sjoerd H, Verdegaal Els M, Heck Albert J R, Samatar Ahmed A, Beijnen Jos H, Altelaar A F Maarten, Peeper Daniel S
Abstract excerpt
No effective targeted therapy is currently available for NRAS mutant melanoma. Experimental MEK inhibition is rather toxic and has only limited efficacy in clinical trials. At least in part, this is caused by the emergence of drug resistance, which is commonly seen for single agent treatment and shortens clinical responses. Therefore, there is a dire need to identify effective companion drug targets for NRAS...
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