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Phenformin’s impact on lifespan in <i>C. elegans</i> is resilient to environmental factors that inhibit metformin-induced longevity downstream of <i>skn-1/</i> Nrf and AMP-activated protein kinase

2023-09-21

Abstract excerpt

Despite being principally prescribed to treat type 2 diabetes, biguanides, especially metformin and phenformin, have been shown to extend lifespan and healthspan in preclinical models, and to reduce the impact of aging-associated diseases such as cancer. While there have been conflicting results in studies involving rodents and humans, consistent evidence from laboratories worldwide, including our own, indicates m...

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Literature Corpus work
d0d06881-b2a2-5715-9861-0d988db5dda7
DOI
10.1101/2023.09.21.558710
Open publication

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Phenformin’s impact on lifespan in <i>C. elegans</i> is resilient to environmental factors that inhibit metformin-induced longevity downstream of <i>skn-1/</i> Nrf and AMP-activated protein kinaseDOI 10.1101/2023.09.21.558710
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