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Synergic effect of diabetes mellitus and H. pylori infection on proliferation of cells via downregulating the expression of PTEN by hypermethylating its promoter region

2020-04-07

Abstract excerpt

<title>Abstract</title> <p>Background It has been reported that CagA of H. pylori reduced the expression of PTEN by enhancing its promoter methylation. Furthermore, DM may also promote the methylation status of PTEN, a tumor suppressor gene in Gastric cancer. It is intriguing to explore whether DM may strengthen the tumorigenic effect of HP by promoting the methylation of PTEN promoter and whether the administrat...

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Literature Corpus work
d0a9d9a0-01ab-5b28-9d9b-66ed7eb3e8fc
DOI
10.21203/rs.3.rs-20761/v1
Open publication

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