Article

Synergistic Effect of Epigenetic Modulator Decitabine and Metformin in the Battle Against Gastric Cancer: A Potential Therapeutic Strategy

2025-09-11

Abstract excerpt

<title>Abstract</title> <p> The 5-year global survival rate of patients with gastric cancer (GC) is approximately 20%; however, 74% of these patients survived for up to 1 year with effective therapy. The anticancer effects of metformin, an antidiabetic agent, and 5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), a DNA methyltransferase inhibitor that leads to malignant cell differentiation and apoptosis, have been...

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Literature Corpus work: a1f889c3-8b16-52a2-beee-78ec8adbfc70
DOI: 10.21203/rs.3.rs-7382082/v1

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