Article

Knockdown of MBD3 Promotes Pluripotency and In Vitro Differentiation Ability of Bovine iPSCs by Reducing DNA Damage via HIF1A During Reprogramming

2025-01-27

Abstract excerpt

The DNA damage response (DDR) is susceptible to occurrence during the reprogram-ming process induced by Yamanaka factors, which constrains the generation and ap-plication of induced pluripotent stem cells (iPSCs). The present study demonstrates that the knockdown (KD) of MBD3, a member of the nucleosome remodeling and deacetylase (NuRD) complex, reduced DDR during the early stages of bovine somatic cell re-program...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d09a7317-07bc-5522-8d31-ffd6458720f3
DOI: 10.20944/preprints202501.2005.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Knockdown of MBD3 Promotes Pluripotency and In Vitro Differentiation Ability of Bovine iPSCs by Reducing DNA Damage via HIF1A During ReprogrammingDOI 10.20944/preprints202501.2005.v1Read

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naïve PluripotencySemantic proximity Read

Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogrammingSemantic proximity Read

TET3 overexpression facilitates DNA reprogramming and early development of bovine SCNT embryosSemantic proximity Read

H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogrammingSemantic proximity Read

Imprinted Genes and Satellite Loci Are Differentially Methylated in Bovine Somatic Cell Nuclear Transfer ClonesSemantic proximity Read

Sexual dimorphic expression and release of transcription factors in bovine embryos exposed to oxidative stressSemantic proximity Read

DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryosSemantic proximity Read

Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear TransferSemantic proximity Read

Transcriptional memory inherited from donor cells is a developmental defect of bovine cloned embryosSemantic proximity Read

BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesisSemantic proximity Read

Sperm-borne miR-449b influences cleavage, epigenetic reprogramming and apoptosis of SCNT embryos in bovineSemantic proximity Read

Melatonin significantly improves the developmental competence of bovine somatic cell nuclear transfer embryosSemantic proximity Read